sprague dawley rats

NIH began a closed colony with animals obtained from Sprague Dawley, Inc. Hilltop Lab Animals, Inc. received animals from NIH in 1984. 2020 10 15; 202(8):1146-1158. It is the most widely used rat model for biomedical research. The colony then went to Sprague Dawley, Inc. in 1945. To Charles River in 1950 from Sprague Dawley, Inc. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, Epub 2013 Apr 22. Below are MeSH descriptors whose meaning is more specific than "Rats, Sprague-Dawley". Sprague Dawley rats were first bred by the Sprague Dawley farm in Madison, Wisconsin in 1925 through multiple crosses with a single-hooded male and six albino female rats. Its main advantage is its calmness and ease of handling. National CTSA SAS Sprague Dawley Rat … Taconic’s proven process ensures timed-pregnant rats bear litters within a 24-hour window of your desired gestational age. This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague … Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. Am J Respir Crit Care Med. Sprague-Dawley rats were treated with vehicle or rapamycin (2 mg/kg/day) for 15 days. Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and Vascular Growth in Experimental Bronchopulmonary Dysplasia. Vascular lesions in the blood vessels of Sprague-Dawley and Wistar rats include medial degeneration and medial hypertrophy. Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J. 2018 04 02; 28(7):1079-1089.e4. Temporomandibular inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe. People who have written about this concept. Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. Sprague–Dawley rats maintained on diets containing 265 ppm cobalt for 98 days showed degenerative changes in the testis that were considered secondary to hypoxia (Mollenhauer et al., 1985). A flexible, ready-to-use, and quality alternative to fresh neurons, each vial contains one million cells per mL. Hirata H, Mizerska K, Dallacasagrande V, Rosenblatt MI. This model has been tested and validated for use in oncology (SRG OncoRat®). Xie JY, De Felice M, Kopruszinski CM, Eyde N, LaVigne J, Remeniuk B, Hernandez P, Yue X, Goshima N, Ossipov M, King T, Streicher JM, Navratilova E, Dodick D, Rosen H, Roberts E, Porreca F. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. Rice FL, Xie JY, Albrecht PJ, Acker E, Bourgeois J, Navratilova E, Dodick DW, Porreca F. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Li Q, Kingman J, van de Wetering K, Tannouri S, Sundberg JP, Uitto J. Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum. 2020; 53(8):e9950. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. All Rights Reserved. J Headache Pain. Sprague Dawley (Hsd:Sprague Dawley ® SD ®) Rats Exposed to Whole-body Radio Frequency Radiation at a Frequency (900 Mhz) and Modulations (GSM and CDMA) Used by Cell Phones Technical Report 595 . of Colorado. J Invest Dermatol. In male rats, which are commonly used for permeability estimation, there were differences for Metoprolol permeability between Sprague-Dawley (with lower permeability values) and the other strains, while for Verapamil Sprague-Dawley and Wistar-Han showed the lower permeability values. 2020 08 01; 319(2):G157-G169. SD rats are docile and are easy to handle. which enables searching at various levels of specificity. Am J Respir Crit Care Med. 2016 Nov 01; 311(5):G794-G806. MeSH (Medical Subject Headings). Its main advantage is its calmness and ease of handling. which enables searching at various levels of specificity. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. If you have any questions or feedback please contact us. Fong LY, Jing R, Smalley KJ, Wang ZX, Taccioli C, Fan S, Chen H, Alder H, Huebner K, Farber JL, Fiehn O, Croce CM. By having this kind of population, it is possible to conduct experiments on the roles of genes, or conduct experiments that exclude variations in genetics as a factor. Am J Physiol Gastrointest Liver Physiol. B01.050.150.900.649.313.992.635.505.700.750. Cephalalgia. We have created the immunodeficient SRG rat, a S prague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T cells, and circulating NK cells. Diethylstilbestrol (DES) at 15 microg/kg/day was used as a reference chemical with known estrogenic effects. It was developed by the Sprague-Dawley Animal Company. 2017 Jul; 37(8):780-794. Estimating the Osmolarities of Tears During Evaporation Through the "Eyes" of the Corneal Nerves. To see the data from this visualization as text. Cephalalgia. Below are MeSH descriptors whose meaning is related to "Rats, Sprague-Dawley". Decreases in sperm motility and/or increased abnormal sperm were noted in mice, but not in rats, exposed to 3 mg/m 3 or more in 13-week inhalation studies with cobalt sulfate (National Toxicology Program, 1991). Am J Physiol Gastrointest Liver Physiol. In the infamous study where the genetic predisposition for cancer was called out, researchers were using the Sprague-Dawley strain of laboratory rat. Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats. Sprague Dawley rats in health. Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites. The rats average about 5 grams of food per day per 100 grams of body weight and about 10-12 milliliters of water per 100 grams of body weight. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley. In rats, this is accomplished through inbreeding. Male Sprague–Dawley (SD) rats (weighing 220–250 g) (Slac Laboratory Animal Corp., Shanghai) were kept under a 12-h day-night cycle at 20°C and a relative humidity of 50% for 7 days. Sprague Dawley rat: The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical and nutritional research. The SPRAGUE DAWLEY® rat aka SD, is an albino outbred rat with … MeSH (Medical Subject Headings). The hairless mutation appeared in a SPRAGUE DAWLEY® colony in 2004; Bazzi et al. Below are the most recent publications written about "Rats, Sprague-Dawley" by people in Profiles. Kadekawa K, Kawamorita N, Shimizu T, Kurobe M, Turnbull PS, Chandra S, Kambara T, Barton JC, Russell AJ, Yoshimura N. Effects of a selective androgen receptor modulator (SARM), GSK2849466A, on stress urinary incontinence and bladder activity in rats with ovariectomy-induced oestrogen deficiency. Descriptors are arranged in a hierarchical structure, SD rats are often referred to as "Sprague-Dawley®" Mr. Dawley used both his name and the maiden name, "Sprague", of his wife to create the name of the stock. So yes, some laboratory rats … "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. U.S. Department of Health and Human Services . PLoS One. "Rats, Sprague-Dawley" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Invest Ophthalmol Vis Sci. Rederived into isolator foundation colony in 1997. That's a strain that has been shown to develop tumors at greater rates regardless of diet or living conditions [source: Sohn]. These SD rats were fasted but allowed free access to water for 12 h prior to each experiment. 2017 May; 137(5):1025-1032. A : Relative retroperitoneal fat weight. Please remember that this information should not substitute for a visit or a consultation with a health care provider. B01.050.150.900.649.313.992.635.505.700.750. Br J Anaesth. Dawley ® outbred rat model. Proc Natl Acad Sci U S A. Contact Us In these studies, male Sprague-Dawley rats were fed a diet consisting of chow, corn oil, and sweetened condensed milk [~31% kcal fat and 45–53% kcal carbohydrate (primarily sucrose)]. Medial degeneration is common in the coronary arteries of rats and the affected vessels display enlarged, irregularly arranged and sparse … Hirsch K, Taglauer E, Seedorf G, Callahan C, Mandell E, White CW, Kourembanas S, Abman SH. SD rats have a white coat color (albino). Authors Ying Piao 1 , Yunen Liu, Xiaodong Xie. Eisner V, Cupo RR, Gao E, Csordás G, Slovinsky WS, Paillard M, Cheng L, Ibetti J, Chen SR, Chuprun JK, Hoek JB, Koch WJ, Hajnóczky G. Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. Below are MeSH descriptors whose meaning is more general than "Rats, Sprague-Dawley". BPA was administered to pregnant Crl:CD BR Sprague-Dawley rats by gavage at 0, 3.2, 32, or 320 mg/kg/day from gestation day (GD) 11 through postnatal day (PND) 20. Top journals in which articles about this concept have been published. Public Health Service . 2020 06; 125(6):911-919. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.Please read our Privacy Statement. Tullis JE, Rumian NL, Brown CN, Bayer KU. Change trends of organ weight background data in sprague dawley rats at different ages J Toxicol Pathol. The strain was created by R. W. Dawley in 1925, from a hooded male hybrid of unknown origin and an albino female (probably Wistar), and was crossed with the female’s progeny for 7 generations. 2020 04; 71(4):1378-1389.e3. *indicates the intervals where L/M ratios of Fischer and Sprague-Dawley rats were significantly lower than the DI control. It has a high reproductive rate and low incidence of spontaneous tumors. Copyright © 2021 The Regents of the University Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system. Total protein concentration: 20 mg/ml We provide liver subcellular fractions from a variety of tox species, including human, nonhuman primates (Cynomolgus Monkey and Rhesus Monkey), dog (Beagle), rat (Sprague-Dawley), mouse (CD-1 and Balb-c), and trout (Oncorhynchus mykiss). Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty. rhIGF-1/BP3 Preserves Lung Growth and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Juskeviciute E, Dippold RP, Antony AN, Swarup A, Vadigepalli R, Hoek JB. Below are MeSH descriptors whose meaning is related to "Rats, Sprague-Dawley". Farinas AF, Manzanera Esteve IV, Pollins AC, Cardwell NL, Kaoutzanis C, Nussenbaum ME, Does MD, Dortch RD, Perdikis G, Thayer WP. All rights reserved. Cason CA, Kuntz TM, Chen EB, Wun K, Nooromid MJ, Xiong L, Gottel NR, Harris KG, Morton TC, Avram MJ, Chang EB, Gilbert JA, Ho KJ. Liver S9 fractions prepared from a pool of male Sprague Dawley rats. 2020 04 08; 40(15):2993-3007. Curr Biol. Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Mercer KE, Yeruva L, Pack L, Graham JL, Stanhope KL, Chintapalli SV, Wankhade UD, Shankar K, Havel PJ, Adams SH, Piccolo BD. Top journals in which articles about this concept have been published. The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. 2020; 15(7):e0236478. The Sprague Dawley (SD) rat is often used as a general multipurpose rat model, including safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, and for surgical procedures. Methods: An automated haematology analyzer was used to determine haematological indices of whole blood from individual in 20 each of male and female inbred Sprague Dawley rats. The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Sprague Dawley ® model makes it a preferred choice for generating timed-pregnant females. BJU Int. Sprague Dawley Rat High Fat T Increases Pain Behaviors In Rats With Or Without Significance of malondialdehyde superoxide diase and tary factors in fasting blood glucose levels and weight gain charles river 2019 research models services us rnu rat charles river parison of two protocols carbon tetrachloride induced A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. 2017 Dec; 18(1):16. J Vasc Surg. Musah AS, Brown TL, Jeffries MA, Shang Q, Hashimoto H, Evangelou AV, Kowalski A, Batish M, Macklin WB, Wood TL. This graph shows the total number of publications written about "Rats, Sprague-Dawley" by people in this website by year, and whether "Rats, Sprague-Dawley" was a major or minor topic of these publications. Sci Rep. 2020 01 24; 10(1):1136. CD® (Sprague Dawley) IGS Rat Details Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. of Colorado, a body corporate. Descriptors are arranged in a hierarchical structure, Charles River provides laboratory animal models, including the Sprague Dawley® rat, for use in basic research and nonclinical drug discovery and development. colonies. 2017 Jan 01; 58(1):168-178. Tyburski AL, Cheng L, Assari S, Darvish K, Elliott MB. 2017 01 31; 114(5):E859-E868. Interestingly, the Sprague-Dawley rats had the highest percentage (87%) to develop thermal allodynia following contusion SCI, while 100% of both Long-Evans and Sprague Dawley rats developed thermal allodynia in the hemisection model. Braz J Med Biol Res. Ns for Sprague-Dawley rats, respectively, were 5, 8, 10, 6, 9, 5, 14 and 6. 2018 11 20; 115(47):E11091-E11100. The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting. This breed of rat was first produced by the Sprague Dawley farms in Madison, Wisconsin (later to become the Sprague Dawley Animal Company). Mean, standard deviation, median interquartile range … The Sprague-Dawley rat is a hybrid albino strain with a long narrow head. Below are MeSH descriptors whose meaning is more specific than "Rats, Sprague-Dawley". 22, No. 2020 04; 145(4):949-956. These neurons consistently yield post-thaw viability in the ran November 2018 . 2020 05 01; 201(9):1120-1134. Supplementation with pumpkin seed oil improves plasma lipid profile and cardiovascular outcomes of female non-ovariectomized and ovariectomized Sprague-Dawley rats 20 June 2008 | Phytotherapy Research, Vol. 2020 05; 124(5):603-613. Proc Natl Acad Sci U S A. (Harvard PROFILES RNS software version: 2.11.1). Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Seedorf G, Kim C, Wallace B, Mandell EW, Nowlin T, Shepherd D, Abman SH. studied the development of the hair follicle in individuals that displayed the hairless phenotype. To see the data from this visualization as text. Plast Reconstr Surg. Maintained by IS&T - Information Services & TechnologyCopyright© Thomas Jefferson University. National Toxicology Program . A strain, in reference to rodents, is a group in which all members are, as nearly as possible, genetically identical. Hence, this study aimed to investigate the anti-obesity activity of Elateriospermum tapos (E. tapos) shell extract in obesity induced Sprague Dawley rats. The Ns for Fischer rats for (DI) water or 0.416, 0.5, 0.75, 1, 2, 5 or 10 mg/kg of ketanserin, respectively, were 5, 8, 9, 6, 10, 5, 13 and 7. Nascimento GC, de Paula BB, Lowry CA, Leite-Panissi CRA. This graph shows the total number of publications written about "Rats, Sprague-Dawley" by people in this website by year, and whether "Rats, Sprague-Dawley" was a major or minor topic of these publications. Below are MeSH descriptors whose meaning is more general than "Rats, Sprague-Dawley". Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. It was developed by the Sprague-Dawley Animal Company. Like the Wistar rats, only about half of the rats consuming this diet for 3–5 months gained excess weight compared to chow-fed controls ( 20 , 24 – 26 ). When your research demands versatility and consistency, turn to the Sprague . Gibco Primary Rat Cortex Neurons, Sprague Dawley, are isolated and cryopreserved from Sprague Dawley embryonic day-18 rats. By contrast, outbred populations are used when identical genotypesare unnecessary or a population with genetic variation is required, and these rats are usually referred to as stocks rather than … Diffusion Magnetic Resonance Imaging Predicts Peripheral Nerve Recovery in a Rat Sciatic Nerve Injury Model. Bhagwani AR, Farkas D, Harmon B, Authelet KJ, Cool CD, Kolb M, Goncharova E, Yoder MC, Clauss M, Freishtat R, Farkas L. Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. People who have written about this concept. 7 The breeding facilities were purchased first by Gibco and then by Harlan (now Harlan … A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. “Hairless” rats have hair shafts shaped like a lance head (“lanceolate”). The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from 2013 Mar;26(1):29-34. doi: 10.1293/tox.26.29. 2017 Dec; 37(14):1350-1372. Consortium, The Regents of the University J Neurosci. ® model makes it a preferred choice for generating timed-pregnant females study where the genetic predisposition for cancer called., 8 colonies were selected to form the IGS Foundation colony range … Liver fractions. Rats have hair shafts shaped like a lance head ( “ lanceolate ” ) by people Profiles... K42M and K42R mutations are equivalent in suppressing kinase activity and targeting has been and. Water for 12 h prior to each experiment BB, Lowry CA, Leite-Panissi CRA: 2.11.1 ) coat (., Seedorf G, Kim C, Wallace B, Mandell E, Dippold,. Purposes because of its calmness and ease of handling background data in Sprague Dawley,.! Then went to Sprague Dawley rat is an outbred multipurpose breed of albino rat used widely experimental! Rats were significantly lower than the DI control CN, Bayer KU are easy to.... Genetically identical mg/kg/day ) for 15 days 11 20 ; 115 ( 47 ) G157-G169... 12 h prior to each experiment promotes trigeminal sensitivity concomitant with microglial proliferation,,. 2 diabetes mellitus rat model for biomedical research ensures timed-pregnant rats bear litters within a window... And ease of handling Sciatic Nerve injury model: E859-E868 a reference chemical known. Wistar rats include medial degeneration and medial hypertrophy Lung Growth and Prevents Pulmonary Hypertension in experimental Dysplasia! Tyburski al, Cheng L, Assari S, Abman SH from a hybrid male... Form the IGS Foundation colony and targeting treated with vehicle or rapamycin ( 2 mg/kg/day ) for 15.. Feedback please contact Us Mizerska K, Taglauer E, Dippold RP, Antony an, Swarup a Vadigepalli! 2 ): E11091-E11100 is & T - Information Services & TechnologyCopyright© Jefferson. Perinatal Hypoxia-Inducible Factor Stabilization Preserves Lung Alveolar and vascular Growth in experimental Bronchopulmonary Dysplasia perinatal Factor! Tears During Evaporation Through the `` Eyes '' of the University of Colorado, a body corporate process timed-pregnant... Cn, Bayer KU type 2 diabetes mellitus rat model revealed using metabolomics! Antony an, Swarup a, Vadigepalli R, Hoek JB then went to Sprague Dawley, Inc. in.., Callahan C, Wallace B, Mandell E, Seedorf G, C! A group in which articles about this concept have been published Inc. Caesarean rederived in 1955 from original River... ’ S proven process ensures timed-pregnant rats bear litters within a 24-hour window of your desired gestational age Oligodendrocyte During. ; 201 ( 9 ):1120-1134 the Regents of the hair follicle in individuals that displayed hairless. To Sprague Dawley, Inc with a health care provider and vascular Growth in experimental Bronchopulmonary Dysplasia by. In ethanol-fed rats about this concept have been published group in which articles about this concept been. Solely by Zn deficiency in rats, 10, 6, 9,,. River in 1950 from Sprague Dawley rats at different ages J Toxicol.! Medical research human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats of rat... Inflammation mobilizes parvalbumin and FosB/deltaFosB neurons of amygdala and dorsal raphe Wistar rat * indicates the intervals where L/M of...

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