Hepatic Transcriptome Analysis Revealing the Molecular Pathogenesis of Type 2 Diabetes Mellitus in Zucker Diabetic Fatty Rats. COVID-19 is an emerging, rapidly evolving situation. 2019. Effects of prolonged type 2 diabetes on mitochondrial function in cerebral blood vessels. HHS Please enable it to take advantage of the complete set of features! Epub 2020 Aug 28. Arrested Net Hepatic Glycogen Flux in Zucker Diabetic Fatty Rats (ZDF) Acute changes in net hepatic g Acute changes in net hepatic glucose flux are tightly linked to regulation of net hepatic glycogen flux. This feature among others, including the development of obesity- and hyperglycemia-related complications, is common between male ZDF rats and humans with type 2 diabetes associated with obesity. 1- Characterization of STZ-Induced Type 2 Diabetes in Zucker Fatty Rats. Zimering MB, Grinberg M, Burton J, Pang K. Endocrinol Diabetes Metab J. In vivo effects of insulin and bis(maltolato)oxovanadium (IV) on PKB activity in the skeletal muscle and liver of diabetic rats. Plasma insulin concentrations were unchanged relative to control fatty rats. 2012;933:125-59. doi: 10.1007/978-1-62703-068-7_9. Dynamics of insulin sensitivity, -cell function, and -cell mass during the development of diabetes in fa/fa rats. Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A. Male Zucker Diabetic Fatty (ZDF) rats with fa / fa -genotype develop obesity, insulin resistance and non-insulin dependent diabetes within the first months of life due to a leptin receptor defect and a genetically reduced insulin promoter activity. Of particular interest are the insights provided by studies of these animals into the mechanism behind the progressive impairment of carbohydrate metabolism. 2020 Mar 9;10(1):90. doi: 10.1038/s41398-020-0767-0. Like NOD mice, biobreeding rats are used as an animal model for Type 1 diabetes. 9 Female ZDF rats with fa / fa -genotype similarly become obese and insulin-resistant, but do not progress to hyperglycaemia, except when fed … Curr Diabetes Rev. doi: 10.1152/ajpendo.00572.2007. RNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty Rats. Epub 2011 Nov 1. We discuss the diabetic features and complications found in ZDF rats and why these animals are widely used as a genetic model for obese type 2 diabetes. 2- Low dose streptozotocin (STZ) combined with high energy intake can effectively induce type 2 diabetes | | Cocoa supplementation improves glucose metabolism in Zucker diabetic fatty (ZDF) rats via multiple mechanisms. We have isolated and described a genetic characteristic in our colony of male fatty Zucker rats that seems to cause a more severe form of diabetes than occurs in most other rat models for NIDDM. The GK rat: a prototype for the study of non-overweight type 2 diabetes. vol. 1998 Dec;125(8):1708-14. doi: 10.1038/sj.bjp.0702245. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation. 2007 Dec;293(6):E1730-5. 2020 Sep 2;68(35):9436-9450. doi: 10.1021/acs.jafc.0c04125. Epub 2019 Sep 6. Stein LM, Lhamo R, Cao A, Workinger J, Tinsley I, Doyle RP, Grill HJ, Hermann GE, Rogers RC, Hayes MR. Transl Psychiatry. Clipboard, Search History, and several other advanced features are temporarily unavailable. Around 9% of the adult population in the world (463 million) suffer from diabetes mellitus. REGULAR ARTICLE Zucker diabetic fatty rats, a model for type 2 diabetes, develop an inner ear dysfunction that can be attenuated by losartan treatment Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. To a much lesser extent, the Zucker rat has been used for investigations of obesity-associated NIDDM (non-insulin-dependent diabetes mellitus). Merdzo I, Rutkai I, Sure VNLR, Katakam PVG, Busija DW. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. NCI CPTC Antibody Characterization Program. 2020 Apr 13;2020:8463858. doi: 10.1155/2020/8463858. The aim of the current study was to predict changes in plasma methionine and homocysteine concentrations after simulated consumption of … Most of them (~90%) belong to type 2 diabetes mellitus (T2DM), which is a common chronic metabolic disorder, and the number of cases has been reported to increase each year. The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, are reviewed. Abstract. This hyperglycemia is associated with impaired pancreatic β-cell function, loss of pancreatic β-cell mass, and decreased responsiveness of liver and extrahepatic tissues to the actions of insulin and glucose. Furthermore, cocoa rich-diets modify the intestinal microbiota composition both in humans and rats in healthy conditions. The occurrence of a genetically based diabetes in a normally outbred colony underscores the importance of genetic traits that interact with obesity in determining diabetes in rodent models. The Zucker diabetic fatty (ZDF) rat is most widely used for studying type 2 diabetes associated with obesity. USA.gov. Am J Physiol Endocrinol Metab. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Here we establish a novel diabetic strain derived from normoglycemic ZF rats. Please enable it to take advantage of the complete set of features! The ZDF phenotype originated from selective breeding of Zucker rats that exhibited high glucose levels in the mid-1970s, and ZDF rats typically develop diabetes at ∼10 wk of age. doi: 10.1152/ajpheart.00341.2019. A noninsulin-dependent diabetes appeared in fatty rats in our Zucker rat colony. ZDF Rat (Obese fa/fa) Details. 2020 Nov 24;11:565858. doi: 10.3389/fendo.2020.565858. A breeding program yielded a genetic pattern of diabetes consistent with a dominant gene not closely linked to the fatty gene. … A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Studies in KK and ob/ob mice and Zucker fatty rats. Since then, fatty rats in our colony periodically expressed the di… Turkenkopf IJ, Kava RA, Feldweg A, Horowitz C, Greenwood MR, Johnson PR. | Although alterations in the methionine metabolism cycle (MMC) have been associated with vascular complications of diabetes, there have not been consistent results about the levels of methionine and homocysteine in type 2 diabetes mellitus (T2DM). Research in diabetes on humans is not possible or only partially possible. Characterization of new oral antidiabetic agent CS-045. doi: 10.1152/ajpendo.00360.2011. Percentage body fat and plasma triglyceride values were decreased in fatty diabetic rats relative to control fatty rats, however, consistent with insulin resistance in fat and liver. Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. USA.gov. Delghingaro-Augusto V, Décary S, Peyot ML, Latour MG, Lamontagne J, Paradis-Isler N, Lacharité-Lemieux M, Akakpo H, Birot O, Nolan CJ, Prentki M, Bergeron R. Am J Physiol Endocrinol Metab. the biobreeding diabetes-prone rat or BBDP rat) is an inbred strain that spontaneously develops autoimmune type 1 diabetes. Koh G, Seino Y, Usami M, Matsuo T, Ikeda H, Yamamoto T, Tsuda K, Taminato T, Imura H. Diabetes. Coenzyme A and Its Thioester Pools in Obese Zucker and Zucker Diabetic Fatty Rats. doi: 10.1152/ajpendo.00255.2006. Effects of Anthocyanin Extracts from Bilberry (. The aim of the current study was to compare the … In ZDF rats, a mutation in the leptin receptor, OB-R, is associated with leptin resistance, obesity, and increased fat content of islets. | acting as an antidiabetic PPAR agonist. 10. HHS eCollection 2020. In our ZF rat colony, we incidentally found fa/fa homozygous male rats having repr… EPMA J. Would you like email updates of new search results? This site needs JavaScript to work properly. 2019 Jul 31;10(3):195-209. doi: 10.1007/s13167-019-00176-z. COVID-19 is an emerging, rapidly evolving situation. eCollection 2020. Importance of imparied insulin-gene expression in occurrence of diabetes in obese rats. Am J Physiol Endocrinol Metab. 2020. Protein kinase ßII in Zucker obese rats compromises oxygen and flow-mediated regulation of nitric oxide formation. Some of these strains, such as most fatty Zucker rat colonies, are typically nondiabetic. Over time, the pancreas becomes exhausted, insulin secretion decreases (as it does in human diabetics) and plasma glucose increases in the face of insulin resistance. Chohnan S, Matsuno S, Shimizu K, Tokutake Y, Kohari D, Toyoda A. Nutrients. 2020 Feb 6;12(2):417. doi: 10.3390/nu12020417. Dorsal vagal complex and hypothalamic glia differentially respond to leptin and energy balance dysregulation. Conclusions: The enlarged islets of Zucker fatty diabetes mellitus rats, which are defec- tive for IIIS, show tumor cell-like metabolic features, including a dedifferentiated state, accelerated aerobic glycolysis and impaired mitochondrial function. 2020 Aug;4(3):413. Circulating Agonist Autoantibody to 5-Hydroxytryptamine 2A Receptor in Lean and Diabetic Fatty Zucker Rat Strains. Guo X, Sun W, Xu G, Hou D, Zhang Z, Wu L, Liu T. Evid Based Complement Alternat Med. Epub 2006 Sep 26. Male Zucker diabetic fatty fa/fa (ZDF) rats develop obesity and insulin resistance at a young age, and then with aging, progressively develop hyperglycemia. The phenotypic changes resemble human type 2 diabetes associated with obesity and therefore the strain is used as a pharmacological model for type 2 diabetes. Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine. DIABETES, VOL. A number of laboratories, including our own, have used obese Zucker and ZDF rats to investigate the consequences of insulin resistance and Type 2 diabetes on cardiac function ( 9 , 30 , 31 ). The Zucker fatty (ZF) rat harboring a missense mutation (fatty, fa) in the leptin receptor gene (Lepr) develops obesity without diabetes; Zucker diabetic fatty (ZDF) rats derived from the ZF strain exhibit obesity with diabetes and are widely used for research on type 2 diabetes (T2D). 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